ALOFEX TABLET (FEXOFENADINE HCI U.S.P) 180mg PACK OF 10 TABLETS on Sale
Description
Alofex 180mg: Your Comprehensive Guide to Fexofenadine HCI U.S.P
Composition:
Composition:
Each filmcoated tablet of Alofex 180mg contains Fexofenadine HCI U.S.P at a concentration of 180mg
Antihistamine and Antiallergic Properties:
Alofex 180mg belongs to a class of drugs known as antihistamines. It is effective in alleviating allergy symptoms by blocking the action of histamines, which are responsible for various allergic reactions
Product Range:
Alofex offers three dosage strengths:
- Alofex 60mg Tablet
- Alofex 120mg Tablet
- Alofex 180mg Tablet
-
- Rapid Absorption: After oral administration, Fexofenadine HCI is rapidly absorbed, with peak plasma concentration achieved approximately 2.6 hours post-dose
- Linear Pharmacokinetics: Fexofenadine s pharmacokinetics are linear for oral doses up to 120mg taken twice daily
- Elimination: The elimination half-life of Fexofenadine is approximately 14.4 hours, allowing for effective symptom relief over an extended period
- Protein Binding: Fexofenadine is about 60% to 70% bound to plasma proteins, primarily albumin
and alpha1 acid glycoprotein. -
- Hepatic Impairment: Patients with hepatic disease showed pharmacokinetics similar to healthy subjects
- Gender: No
significant gender-related differences were observed in the pharmacokinetics of
Fexofenadine - Age: In older
individuals (≥65 years old), peak plasma levels of Fexofenadine were higher
than in younger patients but with similar elimination half-lives - Renal Impairment:
Patients with renal impairment showed increased peak plasma levels and longer
elimination half-lives compared to healthy subjects. Dialysis patients exhibited
even greater peak levels and extended half-lives -
- Alofex 60mg & 120mg: Relief of symptoms associated with seasonal allergic rhinitis in adults and children aged 12 years and older. Symptoms treated effectively include sneezing, rhinorrhea, itchy nose palate, itchy watery red eyes, and throat irritation
- Alofex 180mg: Relief of symptoms associated with chronic idiopathic urticaria
-
- When co-administered with erythromycin or ketoconazole, studies found no significant interactions with Fexofenadine HCI.
- Carcinogenesis: Fexofenadine HCI did not exhibit carcinogenic potential in animal studies.
- Using Fexofenadine HCI during pregnancy should only occur if the potential benefits outweigh the potential risk to the fetus.
- Nursing Mothers: Caution should be exercised when Fexofenadine HCI is administered to nursing women
- Alofex has not established safety and effectiveness in pediatric patients under 12 years old.
- Patients aged 60-68 years showed no significant differences compared to younger patients in placebo-controlled clinical trials.
- Alofex 60mg: Adults and children aged 12 years and older should take 60mg twice daily
- Alofex 120mg: Adults and children aged 12 years and older should take 120mg once daily
- Alofex 180mg: Adults and children aged 12 years and older should take 180mg once daily Patients with decreased renal function may start with a 60mg daily dose
-
Storage:
Store Alofex 180mg at temperatures between 15°C30°C (59°F86°F), protecting it from heat, light, and moisture
How Supplied:
Alofex (Fexofenadine Hydrochloride) tablets are available in blister packs of 10 tablets for each dosage strength (60mg, 120mg, and 180mg)
Important Note: Alofex should be obtained through a prescription from a registered medical practitioner. Keep it out of reach of children
Adverse Reactions:
In clinical trials, adverse events associated with Fexofenadine HCI were similar to those of the placebo group. Common adverse reactions include viral infections (cold flu), nausea, dysmenorrhea, drowsiness, dyspepsia, and fatigue. Importantly, no evidence of tolerance to these effects was observed after prolonged use
Over-dosage:
At high doses, available data indicates that Fexofenadine HCI tolerates well. In the event of an overdose, it is advisable to recommend symptomatic and supportive treatment.
Dosage and Administration:
Contraindications:
Alofex (Fexofenadine HCI) is contraindicated in individuals with known hypersensitivity to any of its ingredients
Precautions:
Therapeutic Indications:
Special Populations:
Active Ingredient Fexofenadine HCI:
Fexofenadine hydrochloride, the key component in Alofex, is a potent histamine H1receptor antagonist. It acts by countering the effects of histamines in the body
Mechanism of Action:
Fexofenadine is an antihistamine with selective peripheral H1 receptor antagonist activity. It effectively inhibits allergic responses, making it a valuable tool in managing allergy symptoms
Pharmacokinetics:
Additional Information
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